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RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer.

Satoshi NakamuraMasato KitazawaYusuke MiyagawaMakoto KoyamaSatoru MiyazakiNao HondoFutoshi MuranakaShigeo TokumaruYuta YamamotoTakehito EharaTomio MatsumuraMichiko TakeokaYuji Soejima
Published in: Technology in cancer research & treatment (2023)
Overall, our findings indicate that RhoA G17E is associated with Vav1 and promoted cancer invasion via matrix metalloproteinase -9 in gastric cancer cells. Thus, RhoA G17E/Vav1 signaling in diffuse gastric cancer may be a useful therapeutic target.
Keyphrases
  • papillary thyroid
  • squamous cell
  • cell migration
  • squamous cell carcinoma
  • lymph node metastasis
  • childhood cancer
  • young adults
  • high grade
  • smooth muscle