Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia.

Sydney FobareOla A ElgamalMark WunderlichEmily StahlAbeera MehmoodCasie FurbyJames R LermaThomas M SesterhennJianmin PanJayesh RaiMegan E JohnstoneAmina Abdul-AzizMariah L JohnsonShesh Nath RaiJohn C ByrdErin Hertlein

Published in: Cancers (2024)

Despite evidence that EZH2 silencing in MDS/MPN can promote AML pathogenesis, our data demonstrate that the therapeutic inhibition of EZH2 in established AML has the potential to improve survival.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
long non coding rna
free survival
long noncoding rna
electronic health record
big data
binding protein
data analysis
artificial intelligence
human health
hematopoietic stem cell
deep learning
cord blood