Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids.
Kenyaita M HodgeVasyl ZhabotynskyAmber A BurtBrian S CarterRebecca C FryJennifer HeldermanJulie A HofheimerElisabeth C McGowanCharles R NealSteven L PastyrnakLynne M SmithSheri A DellaGrottaLynne M DansereauBarry M LesterCarmen J MarsitT Michael O'SheaTodd M Eversonnull nullPublished in: Pediatric research (2024)
This study addresses bronchopulmonary dysplasia (BPD), an important health outcome among preterm neonates, and interrogates a commonly studied pathway, the hypothalamic-pituitary-adrenal (HPA) axis. The combination of BPD, the HPA axis, and epigenetic markers has not been previously reported. In this study, we found that BPD itself was not associated with epigenetic responses in the HPA axis in infants born very preterm; however, antenatal treatment with steroids was associated with epigenetic responses.