The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.
Alvin P Makohon-MooreEvan J LipsonJody E HooperAmanda ZuckerJungeui HongCraig M BielskiAkimasa HayashiCollin J TokheimPriscilla BaezRajya KappagantulaZachary KohutekVladimir MakarovNadeem RiazMichael A PostowPaul B ChapmanRachel KarchinNicholas D SocciDavid B SolitTimothy A ChanBarry S TaylorSuzanne L TopalianChristine A Iacobuzio-DonahuePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
In 4 patients who received immunotherapy, we found 1-3 putative acquired and intrinsic resistance mechanisms coexisting in the same patient, including mechanisms that were shared by all tumors within each patient, suggesting that future therapies directed at overcoming intrinsic resistance mechanisms may be broadly effective.
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