Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater.
Anna KolsiKaisa HaukkaVictorien Tamegnon DougnonAlidéhou Jerrold AgbankpéKafayath FabiyiMarko P J VirtaMikael SkurnikAnu KanteleSaija KiljunenPublished in: Archives of virology (2023)
Acinetobacter baumannii is an opportunistic pathogen that is mostly associated with hospital-acquired infections. The rapid emergence of multi- and pan-drug-resistant Acinetobacter strains poses an increasing challenge in hospitals. Phage therapy offers one treatment option for infections caused by A. baumannii. We isolated three phages from Beninese hospital wastewater - fBenAci001, fBenAci002, and fBenAci003 - that infected clinical A. baumannii strains from Finnish patients. Phylogenetic analysis showed that these phages resemble phages of the genus Friunavirus, family Autographiviridae. The isolated phages meet the requirements set for phages used for phage therapy. However, they were found to have a narrow host range, which may limit their therapeutic use.
Keyphrases
- acinetobacter baumannii
- drug resistant
- pseudomonas aeruginosa
- multidrug resistant
- healthcare
- end stage renal disease
- escherichia coli
- cystic fibrosis
- adverse drug
- ejection fraction
- newly diagnosed
- wastewater treatment
- chronic kidney disease
- emergency department
- peritoneal dialysis
- stem cells
- mesenchymal stem cells
- replacement therapy
- candida albicans
- combination therapy
- cell therapy