Investigation of Chromosome 1 Aberrations in the Lymphocytes of Prostate Cancer and Benign Prostatic Hyperplasia Patients by Fluorescence in situ Hybridization.
Justyna MiszczykMikołaj PrzydaczMichał ZembrzuskiPiotr L ChlostaPublished in: Cancer management and research (2021)
The differences in chromosome 1 aberrations between PCa and BPH demonstrate that lymphocytes taken from patients with prostate cancer have higher radiosensitivity which might be related to hereditary or familiar inclinations. Therefore, this technique may find future application in searching biomarkers of the cellular radiotherapy response in prostate cancer patients.
Keyphrases
- prostate cancer
- benign prostatic hyperplasia
- lower urinary tract symptoms
- copy number
- radical prostatectomy
- end stage renal disease
- peripheral blood
- ejection fraction
- chronic kidney disease
- newly diagnosed
- early stage
- radiation therapy
- peritoneal dialysis
- prognostic factors
- gene expression
- dna methylation
- squamous cell carcinoma
- patient reported outcomes
- current status
- radiation induced
- drug induced
- patient reported