Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort.

Hong-Yi ZhuLenian ZhouQiuke WangQianying CaiFan YangHanqiang JinYiwei ChenYanyan SongChang-Qing Zhang

Published in: Annals of the rheumatic diseases (2023)

With sufficient treatment duration, GLP-1RA therapies might be disease-modifying for KOA patients with comorbid T2DM, possibly mediated by weight loss. Further investigation is needed to elucidate effects of GLP-1RA on disease process, joint structure and patient-reported outcomes of osteoarthritis.

Keyphrases

knee osteoarthritis
weight loss
patient reported outcomes
rheumatoid arthritis
bariatric surgery
roux en y gastric bypass
gastric bypass
glycemic control
disease activity
type diabetes
physical activity
metabolic syndrome
combination therapy
systemic sclerosis