N-nitrosodimethylamine (NDMA) induced apoptosis dependent on Fas/FasL complex in human leukocytes.

Agnieszka IwaniukK GrubczakWioletta Ratajczak-WronaM GarleyKarolina NowakE Jabłońska

Published in: Human & experimental toxicology (2019)

NDMA shows a stronger proapoptotic effect with PMNs than with PBMCs. The Fas/FasL complex, along with other proapoptotic proteins of the receptor (Fas, FADD) and mitochondrial pathway (Noxa, Puma, Bim), plays a key role in the induction of neutrophil apoptosis. Synergic effects of NDMA and FasL which lead to higher induction of apoptosis in PMNs than in PBMCs indicates a multistage and varied regulation of apoptosis in different populations of leukocytes.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
oxidative stress
cell cycle arrest
cell death
endothelial cells
peripheral blood
signaling pathway