Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients.
Kyle JablonskiNicholas A YoungCaitlin HenryKyle CautionAnuradha KalyanasundaramIfeoma OkaforPeter HarbEmmy SchwarzPaul ConsiglioChris M CirimotichAnna BrataszAnasuya SarkarAmal O AmerWael N JarjourNaomi SchlesingerPublished in: PloS one (2020)
Regular, moderate physical activity can produce a quantifiable anti-inflammatory effect capable of partially mitigating the pathologic response induced by intra-articular MSU crystals by downregulating TLR2 expression on circulating neutrophils and suppressing systemic CXCL1. Low and moderate-intensity exercise produces this anti-inflammatory effect to varying degrees, while high-intensity exercise provides no significant difference in inflammation compared to non-exercising controls. Consistent with the animal model, gout patients with higher levels of physical activity have more favorable prognostic data. Collectively, these data suggest the need for further research and may be the foundation to a future paradigm-shift in conventional exercise recommendations provided by Rheumatologists to gout patients.
Keyphrases
- high intensity
- physical activity
- end stage renal disease
- resistance training
- oxidative stress
- newly diagnosed
- anti inflammatory
- uric acid
- chronic kidney disease
- body mass index
- immune response
- prognostic factors
- peritoneal dialysis
- inflammatory response
- signaling pathway
- machine learning
- spinal cord
- pain management
- big data
- binding protein
- hepatitis b virus
- ionic liquid
- radiation therapy
- current status