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Synthesis of Indolyl Phenyl Diketones through Visible-Light-Promoted Ni-Catalyzed Intramolecular Cyclization/Oxidation Sequence of Ynones.

Yufeng ZhouYaping WangPeidong XuWeiwei HanHeng-Ying XiongGuangwu Zhang
Published in: ACS organic & inorganic Au (2023)
The combination of visible light catalysis and Ni catalysis has enabled the synthesis of indolyl phenyl diketones through the cyclization/oxidation process of ynones. This reaction proceeded under mild and base-free conditions and showed a broad scope and feasibility for gram-scale synthesis. Several natural products and biologically interesting molecules could be readily postfunctionalized by this method.
Keyphrases
  • visible light
  • gram negative
  • nitric oxide
  • hydrogen peroxide
  • electron transfer