Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.

Milind M MuleyEugene KrustevAllison R ReidJason J McDougall

Published in: Journal of neuroinflammation (2017)

Neutrophil elastase and PAR2 contribute significantly to the development of joint inflammation, pain, and peripheral neuropathy associated with experimental OA, suggesting their potential as therapeutic targets.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
oxidative stress
chronic pain
pain management
type diabetes
mouse model
metabolic syndrome
climate change
risk assessment
insulin resistance