Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization.
Rui ShangChae Syng LeeHualin WangRoger DyerChristophe NollAndré C CarpentierIbrahim SultanKari AlitaloRobert BoushelBahira HusseinBrian RodriguesPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our study highlights the novel role of VEGFB in LPL-derived FA supply and utilization. In diabetes, loss of VEGFB action may contribute toward metabolic inflexibility, lipotoxicity, and development of diabetic cardiomyopathy.