Therapy for Apnoea of Prematurity: A Retrospective Study on Effects of Standard Dose and Genetic Variability on Clinical Response to Caffeine Citrate in Chinese Preterm Infants.

Xin He Jin-Chun QiuKe-Yu LuHong-Li Guo Ling LiWei-Wei JiaMing-Ming NiYun LiuJing Xu Feng ChenRui Cheng

Published in: Advances in therapy (2020)

Genetic polymorphisms in caffeine's target receptors, but not the exposure levels based on the standard dosing, were associated with variable responses to caffeine therapy in preterm neonates. Future studies are needed to uncover how these genetic variants affect responses to caffeine therapy in this patient population.

Keyphrases

preterm infants
low birth weight
preterm birth
case report
genome wide
stem cells
gene expression
copy number
gestational age
mesenchymal stem cells
cell therapy
case control
sleep apnea