Influence of Previous Disease-Modifying Drug Exposure on T-Lymphocyte Dynamic in Patients With Multiple Sclerosis Treated With Ocrelizumab.

Francesca BovisAlfonso GrimaldiFrancesca BovisMarta PonzanoRoberta FantozziFabio ButtariElisabetta SignorielloGiacomo LusMatteo LucchiniMassimiliano MirabellaMaria CellerinoMatilde IngleseGaia ColaCarolina Gabri NicolettiGiorgia MataluniDiego CentonzeGirolama Alessandra Marfia

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

OCR per se exerts a modest depleting effect on T cells that seems rather due to a carryover phenomenon of previous therapies, particularly FTY. These data may help in the overall evaluation of the risk/benefit profile of treatment sequencing.

Keyphrases

electronic health record
single cell
big data
emergency department
machine learning
artificial intelligence
combination therapy
deep learning