Glutathione S-Transferase Omega-2 and Transforming Growth Factor-β1 Polymorphisms in Iranian Glaucoma Patients.
Shahram BamdadFatemeh Sanie-JahromiMarzieh AlamolhodaNasrin MasihpourMohammad Hossein KarimiPublished in: Journal of ophthalmology (2021)
The presented results revealed that there was a significant association between the ND genotype of GSTO2 and the pathogenesis of glaucoma. Furthermore, this genotype can be considered as a sex-dependent genetic risk factor for the development of glaucoma. In contrast, the CT genotype of TGF-β1 is suggested to be a protective genetic factor against the pathogenesis of glaucoma.
Keyphrases
- transforming growth factor
- optic nerve
- epithelial mesenchymal transition
- end stage renal disease
- chronic kidney disease
- cataract surgery
- ejection fraction
- newly diagnosed
- genome wide
- magnetic resonance
- computed tomography
- contrast enhanced
- single cell
- copy number
- image quality
- dna methylation
- optical coherence tomography
- patient reported outcomes
- signaling pathway
- dual energy