Effects of Somatostatin Receptor Type 2 Antagonism During Insulin-Induced Hypoglycaemia in Male Rats with Pre-Diabetes.

Emily G HoffmanNinoschka C D'SouzaJulian AikenSara AtherleyRichard LigginsMichael C Riddell

Published in: Diabetes, obesity & metabolism (2023)

SSTR2a treatment increases glucagon responsiveness and delays the onset of insulin-induced hypoglycaemia in this rat model of pre-T2D where only a modest deficiency in glucagon counterregulation exists. This article is protected by copyright. All rights reserved.

Keyphrases

type diabetes
glycemic control
high glucose
diabetic rats
cardiovascular disease
drug induced
insulin resistance
metabolic syndrome
adipose tissue
replacement therapy
weight loss
smoking cessation