Pulmonary haemorrhage as the earliest sign of severe leptospirosis in hamster model challenged with Leptospira interrogans strain HP358.

Noraini PhilipSivan Padma PriyaAhmad Hussein Jumah BadawiMohd Hafidz Mohd IzharNorhafizah MohtarrudinTengku Azmi Tengku IbrahimZamberi SekawiVasantha Kumari Neela

Published in: PLoS neglected tropical diseases (2022)

This study deciphered haemorrhage as the earliest manifestation of severe leptospirosis and high levels of IL-1β, CXCL10/IP-10, CCL3/MIP-α, neutrophils and low levels of lymphocytes and platelets serve as a cumulative panel of biomarkers in severe leptospirosis.

Keyphrases

early onset
drug induced
pulmonary hypertension
liver injury
peripheral blood