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Streamline density and lesion volume reveal a postero-anterior gradient of corpus callosum damage in multiple sclerosis.

Maria PetraccaS SchiaviM BattocchioMohamed Mounir El MendiliL FleysherA DaducciM Inglese
Published in: European journal of neurology (2020)
The reduction in CC density across phenotypes suggests an earlier involvement of the posterior regions, followed only at a later stage by involvement of the anterior portions of the CC. Such interhemispheric disconnection seems to develop as a consequence of white matter macroscopic damage and exerts a relevant impact on motor and, to a lesser extent, cognitive disability.
Keyphrases
  • multiple sclerosis
  • white matter
  • oxidative stress
  • functional connectivity
  • genome wide
  • single cell
  • gene expression
  • dna methylation