Epigenetics and its therapeutic potential in colorectal cancer.
Mahsa Akbari OryaniAfsaneh TavasoliMohammad Amin GhalavandRahele Zokaei AshtianiAlisam RezaeeRasadokht MahmoudiHossein GolvariSoroor OwrangiMehdi Soleymani-GoloujehPublished in: Epigenomics (2022)
It is estimated that colorectal cancer (CRC) is the leading cause of cancer-related death around the globe. 'Epigenetics' refers to changes in the chromosome rather than the DNA sequence, which may be transmitted down to daughter cells. Epigenetics is an essential part of controlling the development and variation of a single cell. ncRNAs have a role in epigenetic regulation in CRC, which will be discussed in this review in the context of DNA methylation and histone modifications. A greater survival rate for CRC patients might be achieved by addressing epigenetic mediators, as the authors show. In this review, they aim to thoroughly examine the role of epigenetics in the prognosis, diagnosis and treatment of CRC.
Keyphrases
- dna methylation
- end stage renal disease
- single cell
- gene expression
- induced apoptosis
- ejection fraction
- chronic kidney disease
- genome wide
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- rna seq
- circulating tumor
- copy number
- patient reported outcomes
- oxidative stress
- single molecule
- cell death
- signaling pathway
- nucleic acid