Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis.

Johanna M Melin Maria ForslundSimon J AlesiTerhi PiltonenDaniela Romualdi Poli Mara SpritzerChau Thien TayAlexia Sophie PenaSelma F WitchelAya MousaHelena J Teede

Published in: Clinical endocrinology (2023)

Metformin should remain the first-line insulin sensitising treatment in adults with PCOS for the prevention and management of weight and metabolic features. The addition of thiazolidinediones appears to offer little benefit.

Keyphrases

polycystic ovary syndrome
type diabetes
insulin resistance
glycemic control
body mass index
physical activity
weight loss
adipose tissue
skeletal muscle