SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses.
Leire de Campos-MataSonia Tejedor VaqueroRoser Tachó-PiñotJanet PiñeroEmilie K GrassetItziar Arrieta AldeaNatalia Rodrigo MeleroCarlo CarolisJuan P HorcajadaAndrea CeruttiJudit Villar-GarcíaGiuliana MagriPublished in: Clinical & translational immunology (2021)
Aside from providing new insights into the complexity of the immune response to SARS-CoV-2, our findings indicate that the de novo recruitment of mature B-cell precursors into the periphery may be central to the induction of antiviral immunity.