Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury.

Zhixia SongYao XiaLang ShiHongchu ZhaJing HuangXiaohong XiangHuiming LiHua HuangRuchi YueHongtao WangJiefu Zhu

Published in: Cellular & molecular biology letters (2024)

Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.

Keyphrases

acute kidney injury
oxidative stress
cardiac surgery