Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases.

Kotaro Nishiyama Keita Mori Yusuke Takezawa Mitsuhiko Shionoya

Published in: Chemical communications (Cambridge, England) (2021)

Metal-responsive triplex-forming oligonucleotides (TFOs) were synthesised by incorporating 5-hydroxyuracil (UOH) nucleobases as metal recognition sites. Binding of the UOH-containing TFO to the target natural DNA duplexes was reversibly regulated by the addition and removal of GdIII ions under isothermal conditions.

Keyphrases

nucleic acid
cancer therapy
binding protein
dna binding
single molecule
quantum dots
drug delivery