Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances.
Stephanie LiljaJulia OldenburgAngelika PointnerLaura DewaldMariam LerchBerit HippeOlivier SwitzenyAlexander G HaslbergerPublished in: Oxidative medicine and cellular longevity (2020)
Accumulation of senescent cells in adipose tissue plays an important role in obesity and age-related diseases. SIRT3, located in the mitochondria, can regulate ROS via different pathways. Thus, targeting SIRT3 activating compounds such as EGCG may delay senescence of cells and senescence induced inflammatory processes.
Keyphrases
- induced apoptosis
- dna damage
- oxidative stress
- adipose tissue
- cell cycle arrest
- cell death
- endothelial cells
- insulin resistance
- ischemia reperfusion injury
- stress induced
- signaling pathway
- type diabetes
- high glucose
- diabetic rats
- endoplasmic reticulum stress
- high fat diet
- skeletal muscle
- weight gain
- cancer therapy
- cell proliferation
- tissue engineering