Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage.

Hiroki UchikawaKoki KamenoKeitaro KaiSosho KajiwaraKana FujimoriKen UekawaYukio FujiwaraAkitake MukasaShokei Kim-MitsuyamaYu Hasegawa

Published in: Neurocritical care (2023)

Our study proposes that pretreatment with CLD-targeting PVMs can improve the prognosis of severe SAH through a candidate mechanism of inhibition of posthemorrhagic CBF reduction.

Keyphrases

subarachnoid hemorrhage
cerebral blood flow
brain injury
cerebral ischemia
cancer therapy
drug delivery
blood brain barrier
drug induced