Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome.

Cheng ZhangShi FengZhenhua TuJingqi SunTao RuiXueyou ZhangHaitao HuangQi Ling Shushen Zhen

Published in: Cancer medicine (2021)

Our cancer genome analysis showed a specific genomic profile of sarcomatoid HCC, which were characterized by a high mutation rate in cell cycle genes particularly CDKN2A. The results indicate CDK4/6 inhibitors including abemaciclib, ribociclib and palbociclib as potential therapeutic targets and may help for therapeutic decision making.

Keyphrases

cell cycle
papillary thyroid
cell proliferation
decision making
genome wide
squamous cell
squamous cell carcinoma
risk assessment
copy number
childhood cancer
genome wide identification
genome wide analysis