A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction.
Habib YaribeygiStephen L AtkinMajid RamezaniAmir Hossein SahebkarPublished in: Journal of cellular physiology (2018)
Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR-induced insulin sensitivity and improved insulin resistance.
Keyphrases
- glycemic control
- weight loss
- type diabetes
- blood glucose
- insulin resistance
- bariatric surgery
- end stage renal disease
- roux en y gastric bypass
- metabolic syndrome
- ejection fraction
- chronic kidney disease
- cardiovascular disease
- newly diagnosed
- skeletal muscle
- high fat diet
- physical activity
- peritoneal dialysis
- high glucose
- blood pressure
- patient reported outcomes
- oxidative stress
- endothelial cells
- combination therapy