Semi-refined carrageenan promotes generation of reactive oxygen species in leukocytes of rats upon oral exposure but not in vitro.
Anton S TkachenkoYurii G KotValeriy A KapustnikValeriy V MyasoedovNataliia I MakieievaTetyana O ChumachenkoAnatolii I OnishchenkoYevgeniya M LukyanovaOksana A NakonechnaPublished in: Wiener medizinische Wochenschrift (1946) (2020)
Food-grade carrageenan can enter leukocytes without affecting ROS generation as a result of incubation for 2 h with leukocyte suspensions. On the contrary, oral exposure to E407a is accompanied by ROS overproduction by white blood cells, suggesting an indirect mechanism for the stimulation of ROS synthesis in vivo. E407a promotes cell death of leukocytes both in vivo and in vitro.