Spatial transcriptomics combined with single-cell RNA-sequencing unravels the complex inflammatory cell network in atopic dermatitis.
Yasutaka MitamuraMatthias ReigerJuno KimYi XiaoDamir ZhakparovGe TanBeate RückertArturo O RinaldiKatja BaerenfallerMübeccel AkdişMarie-Charlotte BrüggenKari Christine NadeauPatrick M BrunnerDamian RoqueiroClaudia Traidl-HoffmanMübeccel AkdisPublished in: Allergy (2023)
In this study, we show the unknown cellular crosstalk in leukocyte-infiltrated area in lesional skin. Our findings provide a comprehensive in-depth knowledge of the nature of AD skin lesions to guide the development of better treatments.