Glucolipotoxicity and GLP-1 secretion.

Jung-Hee HongDae-Hee KimMoon Kyu Lee

Published in: BMJ open diabetes research & care (2021)

These results provide evidence for the first time that glucolipotoxicity could affect GLP-1 secretion through changes in glucose and lipid metabolism, gene expressions, and proglucagon biosynthesis and suggest the interrelationship between glucolipotoxicities of L-cells and β-cells which develops earlier than that of L-cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
metabolic syndrome
oxidative stress
skeletal muscle
insulin resistance
weight loss