Endocarditis Caused by Candida parapsilosis Presenting With Severe Thrombocytopenia in a Patient With Tetralogy of Fallot.
Andrew M FreddoSwati MathurHillary DunlevyJames JaggersAmber D KhannaPublished in: World journal for pediatric & congenital heart surgery (2021)
Infective endocarditis (IE) occurs more frequently in individuals living with congenital heart disease, often with high morbidity and mortality. Although gram-positive bacterial infections commonly cause IE, prosthetic valves are a known risk factor for fungal IE. We report a case of prosthetic pulmonary valve Candida parapsilosis IE in a 58-year-old male with repaired tetralogy of Fallot. He presented with fatigue, petechiae, and hematochezia. He had severe thrombocytopenia from idiopathic/immune thrombocytopenia purpura, which resolved with steroids and immunoglobulin. Treatment with antifungals as well as a surgical pulmonary valve replacement resulted in recovery without relapse at greater than a year.
Keyphrases
- aortic valve
- pulmonary hypertension
- mitral valve
- candida albicans
- aortic stenosis
- case report
- early onset
- transcatheter aortic valve replacement
- aortic valve replacement
- biofilm formation
- transcatheter aortic valve implantation
- gram negative
- left ventricular
- sleep quality
- drug induced
- ejection fraction
- depressive symptoms
- combination therapy
- cystic fibrosis
- physical activity
- replacement therapy