Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development-An Overview.
Monika DawidEwa MlyczyńskaMałgorzata JurekNatalia RespektaKarolina PichPatrycja KurowskaWiktoria GierasTomasz MilewiczMalgorzata Kotula-BalakAgnieszka RakPublished in: Cells (2021)
The apelinergic system, which includes the apelin receptor (APJ) as well as its two specific ligands, namely apelin and ELABELA (ELA/APELA/Toddler), have been the subject of many recent studies due to their pleiotropic effects in humans and other animals. Expression of these factors has been investigated in numerous tissues and organs-for example, the lungs, heart, uterus, and ovary. Moreover, a number of studies have been devoted to understanding the role of apelin and the entire apelinergic system in the most important processes in the body, starting from early stages of human life with regulation of placental function and the proper course of pregnancy. Disturbances in the balance of placental processes such as proliferation, apoptosis, angiogenesis, or hormone secretion may lead to specific pregnancy pathologies; therefore, there is a great need to search for substances that would help in their early diagnosis or treatment. A number of studies have indicated that compounds of the apelinergic system could serve this purpose. Hence, in this review, we summarized the most important reports about the role of apelin and the entire apelinergic system in the regulation of placental physiology and pregnancy.
Keyphrases
- preterm birth
- pregnancy outcomes
- endothelial cells
- case control
- gene expression
- oxidative stress
- endoplasmic reticulum stress
- emergency department
- cell death
- signaling pathway
- drinking water
- cell proliferation
- atomic force microscopy
- vascular endothelial growth factor
- adverse drug
- high speed
- replacement therapy
- drug induced
- electronic health record