Differential Effects of Integrin Blockade on Gut and Sacroiliac Joint Inflammation.

α 4 β 7 is a prototypic gut integrin that regulates homing of memory and effector T cells to the gut. 1 Vedolizumab is an anti-α 4 β 7 monoclonal antibody and is approved by the US Food and Drug Administration to treat ulcerative colitis and Crohn disease (CD). 1 .