E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis.

Cuicui XiaoJiao GongYusheng JieWeicheng LiangYan TaiWei QinTongyu LuYutian ChongChaojin Chen Bo Hu Qi Zhang

Published in: Journal of clinical and translational hepatology (2023)

We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis, which was regulated by its upstream transactivator, E2F1. The role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

Keyphrases

nlrp inflammasome
signaling pathway
risk assessment
combination therapy
human health
replacement therapy