The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp3 )-H Alkylation/Arylation.
Lumin ZhangXiaojia SiYangyang YangMarc ZimmerSina WitzelKohei SekineMatthias RudolphA Stephen K HashmiPublished in: Angewandte Chemie (International ed. in English) (2019)
Herein we report a highly selective photoredox C(sp3 )-H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3 )-H alkylation/arylation of ethers. A selective late-stage modification of (-)-ambroxide has also been conducted to demonstrate the applicability of the method.