The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp3 )-H Alkylation/Arylation.

Lumin ZhangXiaojia SiYangyang YangMarc ZimmerSina WitzelKohei SekineMatthias RudolphA Stephen K Hashmi

Published in: Angewandte Chemie (International ed. in English) (2019)

Herein we report a highly selective photoredox C(sp3 )-H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3 )-H alkylation/arylation of ethers. A selective late-stage modification of (-)-ambroxide has also been conducted to demonstrate the applicability of the method.

Keyphrases

transition metal
visible light
reduced graphene oxide
room temperature
metal organic framework
oxide nanoparticles
gold nanoparticles
highly efficient
carbon dioxide