Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.
Wen-Yueh HungWei-Jiunn LeeGuo-Zhou ChengChing-Han TsaiYi-Chieh YangTsung-Ching LaiJi-Qing ChenChi-Li ChungJer-Hwa ChangMing-Hsien ChienPublished in: Cellular oncology (Dordrecht) (2021)
Our results indicate that MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.