Differential effects of right and left heart failure on skeletal muscle in rats.
Fabienne KnappBernd NiemannLing LiNicole MolendaMichael KrachtRainer SchulzSusanne RohrbachPublished in: Journal of cachexia, sarcopenia and muscle (2020)
Manifold skeletal muscle alterations are more pronounced in LV failure compared with RV failure despite a similar ventricular impairment. Most of the catabolic changes were observed in soleus or gastrocnemius muscle rather than in the constantly active diaphragm. Mitochondrial dysfunction and up-regulation of myostatin were identified as the earliest signs of skeletal muscle impairment.