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Differential effects of right and left heart failure on skeletal muscle in rats.

Fabienne KnappBernd NiemannLing LiNicole MolendaMichael KrachtRainer SchulzSusanne Rohrbach
Published in: Journal of cachexia, sarcopenia and muscle (2020)
Manifold skeletal muscle alterations are more pronounced in LV failure compared with RV failure despite a similar ventricular impairment. Most of the catabolic changes were observed in soleus or gastrocnemius muscle rather than in the constantly active diaphragm. Mitochondrial dysfunction and up-regulation of myostatin were identified as the earliest signs of skeletal muscle impairment.
Keyphrases
  • skeletal muscle
  • heart failure
  • insulin resistance
  • mycobacterium tuberculosis
  • left ventricular
  • mechanical ventilation
  • atrial fibrillation
  • adipose tissue
  • intensive care unit