Molecular Features of Parkinson's Disease in Patient-Derived Midbrain Dopaminergic Neurons.

Yong RenHoubo JiangJiali PuLi LiJianbo WuYaping YanGuohua ZhaoThomas J Guttuso Bao-Rong Zhang Jian Feng

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

The unique combination of these quantifiable molecular and cellular traits in iPSC-derived midbrain DA neurons can distinguish healthy subjects from idiopathic PD patients and segregate PD patients with or without rest tremor at onset. The strategy may be used to develop an objective diagnostic test for PD.

Keyphrases

end stage renal disease
spinal cord
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
parkinson disease
deep brain stimulation
single molecule
spinal cord injury
gene expression
patient reported