Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion.

Sylvie Deborde Laxmi Gusain Ann Powers Andrea R Marcadis Yasong Yu Chun-Hao Chen Anna Frants Elizabeth Kao Laura H Tang Efsevia Vakiani Masataka Amisaki Vinod P Balachandran Annalisa Calò Tatiana Omelchenko Kristjan R Jessen Boris Reva Richard J Wong

Published in: Cancer discovery (2022)

How the tumor microenvironment participates in pancreatic cancer progression is not fully understood. Here, we show that SCs are activated by cancer cells and collectively organize into tracks that dynamically enable cancer invasion in a c-Jun-dependent manner. See related commentary by Amit and Maitra, p. 2240. This article is highlighted in the In This Issue feature, p. 2221.

Keyphrases

cell migration
induced apoptosis
papillary thyroid
cell cycle arrest
machine learning
squamous cell
deep learning
peripheral nerve
squamous cell carcinoma
signaling pathway
cell death
lymph node metastasis
cell proliferation
young adults