[ 18 F]DPA-714 PET imaging for the quantitative evaluation of early spatiotemporal changes of neuroinflammation in rat brain following status epilepticus.

Ken-Ichi KanekoSatsuki IrieAya MawatariAmi IgesakaDi HuTakayoshi NakaokaEmi HayashinakaYasuhiro WadaHisashi DoiYasuyoshi WatanabeYilong Cui

Published in: European journal of nuclear medicine and molecular imaging (2022)

F]DPA-714 PET imaging provide valuable evidence for developing new anti-inflammatory therapies for epilepsy. The predominant activation of microglia around epileptogenic regions in the early phase after status epilepticus could be a crucial therapeutic target for curing epilepsy.

Keyphrases

pet imaging
anti inflammatory
positron emission tomography
traumatic brain injury
inflammatory response
high resolution
lipopolysaccharide induced
computed tomography
cognitive impairment
blood brain barrier
brain injury