PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors.

Guillaume BeyrendEsmé van der GrachtAyse YilmazSuzanne van DuikerenMarcel CampsThomas HölltAnna VilanovaVincent van UnenFrits KoningNoel F C C de MirandaRamon ArensFerry Ossendorp

Published in: Journal for immunotherapy of cancer (2019)

This study shows the presence of T cell subsets in the tumor micro-environment expressing both activating and inhibitory receptors. These TAI cells can be targeted by combined immunotherapy leading to improved survival.

Keyphrases

signaling pathway
induced apoptosis
peripheral blood
cell cycle arrest
cancer therapy
oxidative stress