WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.
Beth K NeilsenBinita ChakrabortyJamie L McCallDanielle E FrodymaRichard L SleightholmKurt W FisherRobert E LewisPublished in: BMC cancer (2018)
These data demonstrate a clear role for WDR5 in colon cancer and future studies should examine its potential to serve as a therapeutic target in cancer. Additional studies are needed to fully elucidate if the requirement for WDR5 is independent of or consistent with its role within the COMPASS complex. OICR-9429 treatment was particularly toxic to SW620 and T84 colon cancer cells, two cell lines without mutations in WDR5 and KMT2/MLL proteins suggesting COMPASS complex inhibition may be particularly effective in tumors lacking KMT2 mutations. Additionally, the ability of WDR5 depletion to amplify the toxic effects of radiation presents the possibility of targeting WDR5 to sensitize cells to DNA-damaging therapies.
Keyphrases
- dna damage
- induced apoptosis
- dna methylation
- oxidative stress
- acute myeloid leukemia
- papillary thyroid
- radiation therapy
- dna repair
- machine learning
- big data
- gene expression
- young adults
- circulating tumor
- drug delivery
- deep learning
- cancer therapy
- protein protein
- smoking cessation
- replacement therapy
- radiation induced