Allopurinol-Induced Severe Cutaneous Adverse Drug Reactions: An Analysis of Spontaneous Reports in Malaysia (2000-2018).

Sing Chet LeeWee Kee WoHee Sheong YeohNorleen Mohamed AliVidhya Hariraj

Published in: Therapeutic innovation & regulatory science (2021)

Malaysian pharmacovigilance data show that predictors of allopurinol-induced SCARs were elderly females, patients with underlying renal disease and high allopurinol doses. These patients need close monitoring and must be educated to stop allopurinol at the first signs of rash.

Keyphrases

adverse drug
drug induced
electronic health record
high glucose
diabetic rats
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
early onset
endothelial cells
patient reported outcomes
oxidative stress
middle aged
data analysis
patient reported
stress induced