Balancing cell polarity PARts through dephosphorylation.

André Barros-CarvalhoEurico Morais-de-Sá

Published in: The Journal of cell biology (2022)

How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior-posterior polarity, by counterbalancing aPKC-mediated phosphorylation of PAR-2.

Keyphrases

single cell
cell therapy
induced apoptosis
stem cells
cell death
transcription factor
signaling pathway
cell cycle arrest
cell proliferation