A New HEK293 Cell with CR2 Region of E1A Gene Deletion Prevents the Emergence of Replication-Competent Adenovirus.

Xueqi LianXiaoyan ZhaoJingjing ZhongChenglin ZhangYongchao ChuYaohe WangShuangshuang LuZhimin Wang

Published in: Cancers (2023)

Human adenovirus producer cell clone JH293-C21-C14-C28 with CR2 deletion can effectively prevent the RCA production of replication-competent oncolytic adenovirus; this will provide significant advantages in utility and safety in gene therapy.

Keyphrases

gene therapy
single cell
cell therapy
endothelial cells
genome wide
gene expression
mesenchymal stem cells