A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection.

Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO 3 -based procedure to selectively mediate Nβ-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl and t -Butyl protecting groups.