Celastrol pretreatment attenuates concanavalin A-induced hepatitis in mice by suppressing interleukin-6/STAT3-interleukin-17 signaling.

Dingwu LiJianing ChenBingru LinYanjun GuoJiaqi PanChaohui Yu Xingyong Wan

Published in: Journal of gastroenterology and hepatology (2023)

Celastrol may exhibit immune regulatory effects by regulating IL-6/STAT3-IL-17 signaling in ConA-induced hepatitis, which suggested new potentials for celastrol to be applied in treating immune-mediated liver diseases.

Keyphrases

high glucose
diabetic rats
cell proliferation
endothelial cells
drug induced
type diabetes
oxidative stress
adipose tissue
high fat diet induced