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The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma.

Gillian R NaroNicholas NoveratiTimothy J Craig
Published in: Case reports in medicine (2020)
Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient's morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.
Keyphrases
  • high dose
  • case report
  • low dose
  • blood brain barrier
  • electronic health record
  • stem cells
  • big data
  • risk assessment
  • bone marrow