Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.

Maud MaillardRina NishiiWenjian YangKeito HoshitsukiDivyabharathi ChepyalaShawn H R LeeJenny Q NguyenMary V RellingKristine R CrewsMark LeggasMeenu SinghJoshua L Y SuangAllen E J YeohSima JehaHiroto InabaChing-Hon PuiSeth E KarolAmita TrehanPrateek BhatiaFederico G Antillon KlussmannDeepa BhojwaniCyrine E HaidarJun J Yang

Published in: Journal of the National Cancer Institute (2024)

We recommend more substantial dose reductions to individualize MP therapy and mitigate toxicity in TPMT/NUDT15 IM/IM patients.

Keyphrases

acute lymphoblastic leukemia
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
stem cells
mesenchymal stem cells
bone marrow
patient reported