Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells.

Thassila N PitangaSânzio S SantanaDalila L ZanetteCaroline C GuardaRayra P SantiagoVitor V MaffiliJonilson B LimaGraziele Q CarvalhoJaime R FilhoJunia R D FerreiraMilena M AleluiaValma M L NascimentoMagda O S CarvalhoIsa M LyraValéria M BorgesRicardo R OliveiraMarilda de Souza Gonçalves

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

Thus, our data suggest that caspase-1, IL-1β and IL-18 may contribute to the inflammatory status observed in SCA and that HU treatment may not interfere in this inflammatory pathway.

Keyphrases

induced apoptosis
nlrp inflammasome
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
cell death
electronic health record
big data
machine learning
cell proliferation
artificial intelligence
combination therapy
smoking cessation
replacement therapy